As for social and political statements in network TV? I long ago tuned out those messages. There is nothing on South Park, FG or even The Simpsons I ever take as gospel. Anne is right. When Trey Parker gets on a soapbox, it just ain’t funny.
Something else that occurs to me, and I really don’t mean to beat up on the Griffins here, but I never really like the “Us vs. Them” mentality. I feel like they’re very insular, in a way where everybody is fair game except the fans of the show. I’ll admit, I haven’t watched a full episode in a long time, and I only see snips here and there these days, so I may be off. But it seems like they have a fairly good picture of their fanbase, and they’re exempt from taking shots. The Simpsons, South Park, King of the Hill – they all will make their fan base uncomfortable on occasion. And not in the “Should I be laughing at that?” sense, more in the “Hey, I see a lot of myself in that target of mockery”. I’m not saying everything need to always challenge the audience’s core beliefs, but if you don’t open your audience up to satire, then you’re really just pandering.